Human Calmodulin-like Protein Can Be A Sign of Oral Cancer

Your doctor or dentist will examine your mouth area. The exam may show:
 
A sore on the lip, tongue, or other area of the mouth
An ulcer or bleeding
 
Tests used to confirm oral cancer include:
 
Gum biopsy
Tongue biopsy
 
X-rays and CT scans may be done to determine if the cancer has spread.
 
Treatment
 
Surgery to remove the tumor is usually recommended if the tumor is small enough. Surgery may be used together with radiation therapy and chemotherapy for larger tumors. Surgery is not commonly done if the cancer has spread to lymph nodes in the neck.
 
Other treatments may include speech therapy or other therapy to improve movement, chewing, swallowing, and speech.
 
Human calmodulin-like protein (CLP) is found in many cell types including breast, thyroid, prostate, kidney, and skin. The protein can regulate many cell activities and has a highly specific expression. Gaining an understanding about the expression of CLP in oral epithelial cells and its possible downregulation (or lack of production) in cancer may be a potentially valuable marker in early detection of oral cancer. A new study in the Journal of Prosthodontics found that CLP is expressed in normal human oral muscosal cells and that downregulation of this protein may be an indicator of malignancy or cancer. 
 
Michael D. Brooks, DMD, MS, Richard D. Bennett, PhD, Emanuel E. Strehler, PhD, Thomas J. Sebo, MD, PhD, Stephen E. Eckert, DDS, MS, and Alan B. Carr, DMD, MS used a method of staining oral skin cells to see if they expressed this protein. A breast tissue sample that was known to have this protein was used as a basis for comparison. Normal cells in the mouth also possessed CLP. In malignancy or cancer, the same type of skin cells no longer expressed this protein. 
 
In the areas of cancerous cells, a decrease in CLP occurred. There was a sharp contrast in staining quality and clarity between benign and malignant tissue. In the majority of the cancerous regions, a complete lack of CLP was noted. 
 
This may be significant because calmodulin-like protein could be a marker for normal healthy oral cavity cells and diminished or complete loss of the protein could be an indicator of oral cancer or oral cancer development. 
 
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